![]() ![]() aureus (MRSA) increase the daily risk of hospital death and prolonged hospital stay ( Stewardson et al., 2016). Recently, a multicenter retrospective cohort study reported that bloodstream infections with methicillin-susceptible (MSSA) and -resistant S. aureus infections poses a great threat to public health, especially in children, pregnant women, and postpartum women ( Williamson et al., 2014 Liu et al., 2016 Angelopoulou et al., 2018). The continuous and heavy burden of community- and hospital-acquired S. Staphylococcus aureus is one of the most common pathogens in China, causing a variety of infections, including skin and soft tissue infections (SSTIs), deep-seated abscess, osteoarthritis, necrotizing pneumonia, sepsis, meningitis, and so on ( Qiao et al., 2013 Xiao et al., 2015). aureus from women and children in Guangzhou, China, and provide critical information for the control and treatment of S. These results clarified the molecular epidemiology of S. Virulence genes and antibiograms were closely associated with the clonal lineage. aureus varied, depending on the specimen source. ![]() ST338-III and ST45-IV emerged as two of three major clones in MRSA isolates from women and children in Guangzhou, China, though ST59-MRSA-IV remained the most prevalent MRSA clone. In total, 481 HIS/ASN mutations in rpoB were found in rifampicin-resistant or intermediate-resistant isolates. All ST45 isolates exhibited intermediate or complete resistance to rifampicin. A total of 80% of ST338 isolates were resistant to erythromycin, clindamycin, and tetracycline. All ST338, ST1232, and SCC mec III isolates carried lukF/S-PV genes. Staphylococcal enterotoxin genes seb- seq- sek were strongly associated with ST59 and ST338, while sec was associated with ST45, ST121, ST22, and ST30. ST338-MRSA-III mostly found in pus but hardly in respiratory tract samples while ST45-MRSA-IV was on the opposite, even though they both found in blood and cerebrospinal fluid sample frequently. A total of 58 spa types, 27 sequence types (STs), and 10 clonal complexes (CCs) were identified. aureus isolates (100 from children and 31 from women) were analyzed by spa typing, multi-locus sequence typing, virulence gene and antimicrobial resistance profiling, staphylococcal chromosomal cassette mec typing, and mutation analyses of rpoB. ![]() aureus isolated from patients in four centers for women and children in Guangzhou, China. In this study, we analyzed the molecular epidemiology and antimicrobial resistance of S. aureus strains causing infections in women and children in China have not been characterized. Fixed an issue where the "Empty Recycle Bin" option was sometimes incorrectly unavailable.The prevalent Staphylococcus aureus clones and antibiotic susceptibility profiles are known to change dynamically and geographically however, recent S.Fixed an issue that led to an error when rendering plots for empty data sets.Side panel option to show legends for a plot with more than 10 samples is now enabled.Fixed saving different line colors in plots through the side panel.Plots inside reports are now shown with their saved side panel settings.Fix of potential wrong file being saved when editing a file found via the Local Search Editor.Fixed wrong display of "Supported format" when exporting elements from either the Folder Editor or the Local Search Editor.When installing a workflow with bundled data, it is no longer possible to select a read-only folder for storing the data.All reverse translation would thus default to the standard genetic code. The Reverse Translate tool ignored any genetic code specified in the codon frequency tables.A fix was applied to avoid an exception in circumstances when the cleanup of downloaded files from BLAST failed.Fixed an issue with running BLAST at NCBI where an NCBI-generated error about their CPU usage limit being exceeded was not being reported transparently and a result of "no hits" was being reported instead.Added a work around to a java issue that occasionally resulted in the Workbench displaying an uninformative error and requiring a restart to continue working. ![]()
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